Eflaza 30

Composition

Deflazacort – 30 mg

Packing

Each box contain 10 Alu-Alu strips of 10 tablets

Product Description

Eflaza 30 tablets contain deflazacort. It is a glucocorticoid which is used as anti-inflammatory and immunosuppressant. It is an inactive drug which is becomes active by metabolism to 21-desacetyldeflazacort.

Indications

Anti-inflammatory conditions
Immunosuppressant (For treatment of autoimmune diseases)
Treatment of rejection of transplanted organs
Certain types of cancer

Mechanism of action

It produces its action by preventing the release of chemicals which are important in immune system. These are mainly involved immune and allergic responses which causes inflammation. By reduction in those responses inflammation is reduced. It also decreases white blood cells which are circulating in blood. It also decreases the inflammation chemicals.

Pharmacology

Absorption
After oral administration it is well adsorbed. After absorption it is converted by plasma esterase to its pharmacological active compound by peak plasma concentration achieving in 1.5 – 2hrs.
Distribution
Nearly about 40% of the drug is bound to plasma protein. It binds to plasma protein and blood cell. It does not cross blood brain barrier and not pass through pituitary circulation.
Excretion
The elimination of the drug is through kidney. About 70% of the drug is excreted through urine. 30% of the drug is excreted in feces.

Contraindications

Patients taking immunosuppressant vaccine
Hypersensitivity to any of the ingredient

Precautions

Patient with the history of adrenal suppression or infections
Tuberculosis
Recent heart attack
High blood pressure
Corneal damage
Osteoporosis
Peptic ulcer
During pregnancy and breast feeding
Avoid long term use of medicine
Epilepsy
Increased eye pressure
Can cause increased risk of confusion, irritability and nightmares
Kidney impairment
Hepatic failure
Mood changes
Depression
Suicidal thoughts