Flunarizine – 5 mg
Domperidone – 10 mg
Paracetamol – 325 mg
Each box contain 10 Blister strips of 10 tablets
Flizi DP contains flunarizine, domperidone and paracetamol.
It is non selective blocker for calcium entry with some other actions which includes histamine H1 blocker activity. It is effective in prophylaxis of migraine vertigo of central and peripheral origin. It is also an adjuvant for the therapy of epilepsy and attacks of paralysis. It can also significantly reduce headache frequency.
It is a specific blocker of dopamine receptor. It is used to relieve nausea, vomiting, to increase the transit of food through the stomach.
It is also known as acetaminophen and is widely used as over the counter analgesic and anti-pyretic. It is a mild analgesic which causes relief in mild headaches and other aches and pains. In combination with other drugs like opioid analgesic, paracetamol is used in the management of post surgical pain and severe pain.
- Flunarizine is used to prevent migraine headache pain
- Relieves the symptoms without aura
- Acute migraine attacks
- Occlusion peripheral vascular diseases
- Vertigo of central and peripheral origin
- severity and duration of attacks of paralysis associated with the more serious form of alternating hemiplegia
- Paracetamol causes analgesic and anti-pyretic effect
- Domperidone causes symptomatic relief of erosive or ulcerative GERD
- Domperidone is useful in parkison’s disease
- Domperidone may be used in functional dyspepsia in both adults and children.
It causes inhibition of influx of extracelluar calcium through myocardial and vascular membrane by plugging the channel. The inhibition of calcium causes inhibition of contractile process in smooth muscle. This causes the dilation of coronary and systemic artery, decreases the total peripheral resistance, increases the oxygen delivery to myocardial tissue, decreases the afterload and decreases the blood pressure.
It inhibits the synthesis of prostaglandin synthesis by competing with arachidonic acid for the active site of COX.
It increases the peristaltic stimulation. It facilitates the gastric emptying and decreases the small bowel transit time by increasing the esophageal and gastric peristalsis. The antiemetic property is related to blocking of dopamine activity.
After oral administration about 85% of the drug is absorbed by the body.
Nearly about 99% of the drug is bound to plasma protein. The drug follows hepatic metabolism which involves Cytochrome P450 2C9, Cytochrome P450 2AA6, Cytochrome P450 1A1, Cytochrome P450 1A2 enzymes
It follows biliary excretion and half life is 18 days
It has rapid and complete absorption
The protein binding of the drug is about 25%, it undergoes glucuronidation in liver.
About 80% of acetaminophen is excreted in the urine after conjugation and about 3% of the drug is excreted unchanged.
The drug follows rapid absorption
About 91%-93% of the drug is bound to plasma protein.
About 31-66% of the drug is excreted through urinary and fecal secretion.
- Pregnant patient
- Lactating mothers
- GI obstruction
- UT obstruction
- Acute porphyrias
- Liver Failure
- Serious Kidney Problems
- Overdose of the Drug Acetaminophen
- Poor Nutrition
- Limb splay
- Lateral position
- Absence of ear reflex
- Hypersensitivity to any of the ingredient
- Avoid driving
- Operation of machinery
- CVS disease
- Hepatic or renal diseases
- Pregnant and lactating mothers
- Increased eye pressure
- Atrophic gastritis
- Acute intestinal nephritis
- Long treatment with acid suppressants can cause cyanocobalamin deficiency
- Increased risk of osteoporosis