Flizi 2018-05-21T06:02:47+00:00

Flunarizine   –    10mg

Each box contain 10 Blister strips of 10 tablets

Flizi tablet contains Flunarizine. It is non selective blocker for calcium entry with some other actions which includes histamine H1 blocker activity. It is effective in prophylaxis of migraine vertigo of central and peripheral origin. It is also an adjuvant for the therapy of epilepsy and attacks of paralysis. It can also significantly reduce headache frequency.

  • It is used to prevent migraine headache pain
  • Relieves the symptoms without aura
  • Acute migraine attacks
  • Occlusion peripheral vascular diseases
  • Vertigo of central and peripheral origin
  • Epilepsy
  • severity and duration of attacks of paralysis associated with the more serious form of alternating hemiplegia

It causes inhibition of influx of extracelluar calcium through myocardial and vascular membrane by plugging the channel. The inhibition of calcium causes inhibition of contractile process in smooth muscle. This causes the dilation of coronary and systemic artery, decreases the total peripheral resistance, increases the oxygen delivery to myocardial tissue, decreases the afterload and decreases the blood pressure.    

Absorption

After oral administration about 85% of the drug is absorbed by the body.

Distribution

Nearly about 99% of the drug is bound to plasma protein. The drug follows hepatic metabolism which involves Cytochrome P450 2C9, Cytochrome P450 2AA6, Cytochrome P450 1A1, Cytochrome P450 1A2 enzymes

Excretion

It follows biliary excretion and half life is 18 days

  • Pregnant patient
  • Lactating mothers
  • GI obstruction
  • UT obstruction
  • Acute porphyrias
  • Avoid driving
  • Operation of machinery
  • Epilepsy
  • CVS disease
  • Glaucoma
  • Hepatic or renal diseases
  • Elderly
  • Pregnant and lactating mothers
  • Increased eye pressure

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