
Composition
- Aceclofenac – 100 mg
- Paracetamol – 325 mg
- Serratiopeptidase – 15 mg
Packing
Each box contain 10 Blister strips of 10 tablets
Product Description
Movofen SP is a combination of aceclofenac, paracetamol and serratiopeptidase.
Aceclofenac
It is non-steroidal anti-inflammatory drug. It is mainly used to relieve pain and inflammation occurring in rheumatoid arthritis.
Paracetamol
It is a pain reliever and antipyretic properties. It is mainly used for headache and other minor pains.
Serratiopeptidase
It is a proteolytic enzyme which is produced by enterobacterium serratia. This is present in silk worm intestine and allows the emerging moth to dissolve its cocoon.
Indications
- Fever
- Pain
- Ankylosing spondylitis
- Arthritis
- Blocks COX which causes relief in swelling and inflammation
- Blocks the substances in the body which causes pain and inflammation
Mechanism of action
Paracetamol
Paracetamol is a weak inhibitor for prostaglandin synthesis. It decreases the PG concentration but does not produce action against inflammation in arthritis.
Aceclofenac
It is having higher anti-inflammatory activity. It acts by blocking the action of substances in the body called as COX. Both the drugs produce similar mechanism of actions
Serratiopeptidase
It causes reduction in the exudates phenomena and release of inflammatory mediators. This causes fragmentation and reduces the viscosity of exudates. It has a modulatory effect on acute phase of protein which is involved in the inflammatory process.
Pharmacology
Paracetamol
Absorption
It is rapidly absorbed from the GI tract with the volume of distribution about 50L.
Distribution
It is metabolized in liver into its toxic and non-toxic products.
Excretion
About 85-90% of the drug is excreted in urine.
Aceclofenac
Absorption
The drug is rapidly absorbed into the body with approximately 100% bioavailability.
Distribution
The plasma protein binding of the drug is near to 99.7% and the drug is distributed in synovial fluid
Excretion
About two-third of the drug is excreted in the conjugated form in urine.
Serratiopeptidase
Absorption
The drug is orally absorbed
Distribution
It is well distributed in blood stream
Excretion
The excretion of the drug is through urine and bile
Contraindications
- Severe hepatic impairment
- Hypersensitivity to acetaminophen
- Patients with malnutrition and renal impairment
Precautions
- GI disturbances
- Hepatic impairment
- Alcohol depending patients
- Hypertension or cardiac patients
- Regular monitoring of renal and hepatic functions