- Aceclofenac – 100 mg
- Paracetamol – 325 mg
- Serratiopeptidase – 15 mg
Each box contain 10 Blister strips of 10 tablets
Movofen SP is a combination of aceclofenac, paracetamol and serratiopeptidase.
It is non-steroidal anti-inflammatory drug. It is mainly used to relieve pain and inflammation occurring in rheumatoid arthritis.
It is a pain reliever and antipyretic properties. It is mainly used for headache and other minor pains.
It is a proteolytic enzyme which is produced by enterobacterium serratia. This is present in silk worm intestine and allows the emerging moth to dissolve its cocoon.
- Ankylosing spondylitis
- Blocks COX which causes relief in swelling and inflammation
- Blocks the substances in the body which causes pain and inflammation
Mechanism of action
Paracetamol is a weak inhibitor for prostaglandin synthesis. It decreases the PG concentration but does not produce action against inflammation in arthritis.
It is having higher anti-inflammatory activity. It acts by blocking the action of substances in the body called as COX. Both the drugs produce similar mechanism of actions
It causes reduction in the exudates phenomena and release of inflammatory mediators. This causes fragmentation and reduces the viscosity of exudates. It has a modulatory effect on acute phase of protein which is involved in the inflammatory process.
It is rapidly absorbed from the GI tract with the volume of distribution about 50L.
It is metabolized in liver into its toxic and non-toxic products.
About 85-90% of the drug is excreted in urine.
The drug is rapidly absorbed into the body with approximately 100% bioavailability.
The plasma protein binding of the drug is near to 99.7% and the drug is distributed in synovial fluid
About two-third of the drug is excreted in the conjugated form in urine.
The drug is orally absorbed
It is well distributed in blood stream
The excretion of the drug is through urine and bile
- Severe hepatic impairment
- Hypersensitivity to acetaminophen
- Patients with malnutrition and renal impairment
- GI disturbances
- Hepatic impairment
- Alcohol depending patients
- Hypertension or cardiac patients
- Regular monitoring of renal and hepatic functions