Movozox Tablets


Diclofenac K    –   50 mg
Paracetamol   –   325 mg
Chlorzoxazone   –  250 mg


Each box contain 10 Blister strips of 10 tablets

Product Description

Movozox tablet is a combination of Diclofenac sodium, Paracetamol and Chlorzoxazone.
Diclofenac sodium It is NSAID which is used for inflammation and also produces analgesic effect.
Paracetamol It is also known as acetaminophen and is widely used as over the counter analgesic and anti-pyretic. It is a mild analgesic which causes relief in mild headaches and other aches and pains. In combination with other drugs like opioid analgesic, paracetamol is used in the management of post surgical pain and severe pain.
Chlorzoxazone It is centrally acting muscle relaxant which reduces pain and discomfort of the pain. It mainly acts on spinal cord by depressing reflexes.

Mechanism of action

ParacetamolIt inhibits the synthesis of prostaglandin synthesis by competing with arachidonic acid for the active site of COX.

  • Acute pain
  • Analgesic
  • Antipyretic
  • Treatment of muscle spasm
  • Pain and discomfort
Mechanism of action

Paracetamol It inhibits the synthesis of prostaglandin synthesis by competing with arachidonic acid for the active site of COX.
Chlorzoxazone It prevents the release of histamine and inhibits degranulation of mast cells. It also reduces the inflammatory leukotrienes. It produces its action by inhibiting calcium and potassium influx which causes neuronal inhibition.
Diclofenac sodium It causes inhibition of both leukotriene migration and enzyme COX. This leads to the inhibition of PG synthesis. This produces analgesic effect of the drug by inhibition of PG synthesis.


Absorption It has rapid and complete absorption
Distribution The protein binding of the drug is about 25%, it undergoes glucuronidation in liver.
Excretion About 80% of acetaminophen is excreted in the urine after conjugation and about 3% of the drug is excreted unchanged.
Diclofenac sodium
Absorption After oral administration the drug is absorbed 100% and follows first pass metabolism. Nearly about 50% of the drug is systematically available. The food produces no effect on the drug.
Distribution The apparent volume of distribution of the drug is 1.4 L/kg. Nearly about 99% of the drug is bound to human serum.  It also diffuses into the synovial fluid. The drug is metabolized into five metabolites which produces pharmacological action.
Excretion The drug metabolites are eliminated through metabolism and subsequent urinary and biliary excretion of the glucuronide and the sulfate conjugates. No free unchanged drug is excreted in urine. About 65% of the drug is excreted in urine and 35% is excreted through bile.  The terminal half-life of unchanged diclofenac is approximately 2 hours.
Absorption After administration the drug is well absorbed in the body. Chlorzoxazone acts primarily at the level of the spinal cord and subcortical areas of the brain where it inhibits multisynaptic reflex arcs
Distribution It is well distributed in the body with the blood serum levels attained within first 30 min and peak levels achieved in 1 to 2 hrs after oral administration.
Excretion The drug is excreted in conjugated form as the glucuronide form in urine.

  • Contraindicated in patients with intolerance to the drug
  • Hypersensitivity to diclofenac
  • Any of the allergic reactions
  • In first trimester of the pregnancy
  • Stomach or duodenal bleeding
  • Severe insufficiency of the heart
  • Renal and hepatic insufficiency
  • Hypertension
  • Severe infections
  • Complicated acute abdominal conditions
  • Prolong half life can cause difficulty in achieving steady state of drug in body.
  • Renal disease
  • Hepatic disease
  • Patients with history of any allergic reactions
  • Symptoms of liver dysfunction
  • Sensitive skin reactions including redness or itching