Composition
Methylcobalamin – 1500 mcg
Pyridoxine HCL – 100 mg
Nicotinamide – 100 mg
Packing
Each box contain 5 Blister ampoules of 2 ml
Product Description
Nervoba plus is a combination of methylcobalamin, pydoxine hydrochloride, nicotinamide and benzyl alcohol.
Methylcobalamin is a form of vitaminB12. It is a cobalamin which differs from cyanocobalamin. The cyanide group is replaced by methyl group in methylcobalamin. Octahedral cobalt III is present in the centre.
Indication
- Megaloblastic anemia caused by vitB12 deficiency
- Peripheral neuropathy
- Diabetic neuropathy
- Pernicious anemia
- Amyotrophic lateral sclerosis
Mechanism of action
MethycobalaminIt is the active form of vitamin B12 which a water soluble vitamin. It functions as to transfer methyl group for the regeneration of methionine from homocysteine. It acts as a cofactor for enzyme methionin synthase. In cases of anemia it causes the production of erythrocytes by nucleic acid synthesis in bone marrow.
Pharmacology
Methycobalamin
AbsorptionThe drug is well absorbed in the body with peak concentration achieved after 3hrs.
DistributionAfter oral administration it is well distributed
ExcretionThe drug is excreted through urine.
Contraindications
- Decreases the GI absorption with neomycin
- Reduces the serum concentrations of oral contraceptives
Precautions
- Polycythemia rubra vera
- Megaloblastic anemia
- Cobalt or cobalamin allergy
- Leber’s disease.