Composition
Nimesulide – 100 mg
Mouth dissolving
Packing
Each box contain 20 Blister strips of 10 tablets
Product Description
Nicare MD contains nimesulide which is in mouth dissolving form of tablet. Nimesulide is selective COX-2 NSAID which possesses analgesic and antipyretic properties. It is mainly used for the treatment of acute pain, osteoarthritis and primary dysmenorrhoea in adolescents.
Indication
- Painful inflammatory conditions
- Back pain
- Dysmenorrhea
- Postoperative pain
- Osteoarthritis
- Fever
Mechanism of action
Nimesulide
It produces its therapeutic effect by targeting the key mediators of inflammatory process which includes COX-2 mediated prostaglandins, free radicals, histamine and proteolytic enzymes.
Absorption
After oral administration it is rapidly adsorbed by the body.
Distribution
It undergoes extensive biotransformation to 4-hydroxynimesulide which is a biologically active form of the drug. The drug produces its pharmacological effect within 15mins from the drug intake. The protein binding of the drug is more than 97.5%
Excretion
The half life of the drug is 1.8–4.7 hours. About 50% of the drug is excreted through kidney and 29% in feces.
Pharmacology
Contraindications
- Severe hepatic disease
- Severe kidney disease
- Bleeding disorder
- Hypersensitivity
- Stomach problems
- Gastrointestinal ulcers
Precautions
- Diabetes mellitus
- Alcohol abuse
- Colitis
- Crohn’s disease
- Diverticulitis
- Gastric ulcer