Movofen-DS Suspension

Composition

Acelofenac     –     50 mg
Paracetamol   –  250 mg

Packing

Each box contain 60 ml Bottle

Product Description

Aceclofenac
It is non-steroidal anti-inflammatory drug. It is mainly used to relieve pain and inflammation occurring in rheumatoid arthritis.
Paracetamol
It is a pain reliever and antipyretic properties. It is mainly used for headache and other minor pains.

Indication

• Fever
• Pain
• Ankylosing spondylitis
• Arthritis
• Blocks COX which causes relief in swelling and inflammation
• Blocks the substances in the body which causes pain and inflammation

Mechanism of action

Paracetamol
Paracetamol is a weak inhibitor for prostaglandin synthesis. It decreases the PG concentration but does not produce action against inflammation in arthritis.
Aceclofenac
It is having higher anti-inflammatory activity. It acts by blocking the action of substances in the body called as COX.
Both the drugs produce similar mechanism of actions

Pharmacology

Paracetamol
Absorption
It is rapidly absorbed from the GI tract with the volume of distribution about 50L.
Distribution
It is metabolized in liver into its toxic and non-toxic products.
Excretion
About 85-90% of the drug is excreted in urine.
Aceclofenac
Absorption
The drug is rapidly absorbed into the body with approximately 100% bioavailability.
Distribution
The plasma protein binding of the drug is near to 99.7% and the drug is distributed in synovial fluid
Excretion
About two-third of the drug is excreted in the conjugated form in urine.

Contraindications

• Severe hepatic impairment
• Hypersensitivity to acetaminophen
• Patients with malnutrition and renal impairment

Precautions

• GI disturbances
• Hepatic impairment
• Alcohol depending patients
• Hypertension or cardiac patients
• Regular monitoring of renal and hepatic functions