Movogesic gel 10mg 2018-09-08T19:57:16+00:00

Oleum Lini   –  3.00%w/w

Diclofenac Diethylammonium   –    1.16%w/w

Methyl Salicylate   –  10.00%w/w

Menthol   –   5.00%w/w

Benzyl Alcohol   –   1.10 %w/w

10 gm tube

Movogesic gel contains Oleum lini, Diclofenac Diethyl,Methyl Salicylate, Menthol, Benzyl alcohol.

Diclofenac diethyl

It is NSAID and applied to skin to reduce the inflammation and to reduce pain.

Methyl salicylate

It is organic ester extracted from plant species mainly wintergreens. It is also used synthetically as fragrance in foods and beverages. When they applied to the skin it causes sudden cooling and warm feeling.

Oleum lini

It is a solution which contains various compositions of sulfur trioxide and more specifically disulfuric acid.

Menthol

It is an organic compound which is synthetically obtained from cornmint or other mint oils. It is local anesthetic and counterirritant properties.

Benzyl alcohol

It is an aromatic alcohol which is colorless liquid. It is a bacteriostatic preservative at lower concentrations.

  • Musculoskeletal complaints
  • Arthritis
  • Rheumatoid arthritis
  • Polymyositis
  • Dermatomyositis
  • Osteoarthritis
  • Spondylarthritis or Ankylosing spondylitis
  • Gout attacks
  • Acute migraines
  • Post operative and post traumatic pain
  • Inflammation

Diclofenac diethyl

It causes the inhibition of prostaglandin synthesis by causing the inhibition of COX. It also possesses bacteriostatic activity by inhibition of bacterial DNA synthesis.

Methyl salicylate

It is NSAIDs with analgesic properties. The action is caused by inhibition of PG synthesis. The primary metabolite of methyl salicylate is salicylate which inhibits the synthesis of PG by irreversibly acetylating and inactivating COX.

Diclofenac diethyl

Absorption

After dermal application it is well absorbed by the body about 100%. The drug follows first pass metabolism so 50% of the drug is systematically available. The mean absolute bioavailability is 55% and Tmax is 2.3 hr.

Distribution

The Vd is about 1.4l/kg. About 99% of the drug is bound to protein. The diclofenac converts to its metabolites like 4′-hydroxy-, 5-hydroxy-, 3′-hydroxy-, 4′,5-dihydroxy- and 3’hydroxy-4′-methoxy-diclofenac.

Excretion 

The drug is excreted through urinary and biliary secretion.

Methysalicylate

Absorption

The dermal bioavailability is 11.8%-30.7%. The presence of methyl- salicylate causes more penetration into the skin.

Distribution

It is distributed throughout the body tissues. Salicylate is transported by low capacity saturated system out of the CSF. It follows hepatic metabolism which form conjugation with glycine to form salicyluric acid.

Excretion

It is excreted in free form in urine as salicylate acid (10%) salicyluric acid (75%), salicylic phenolic (10%) and acyl (5%) glucuronides, and gentisic acid (less than 1%). Excretion depends on the pH of the urine.

  • Hypersensitivity against diclofenac
  • Associated allergic reactions
  • Third trimester of pregnancy
  • Patients with GI bleeding
  • Patients with pre-existing hepatic porphyria
  • Fluid retention and heart failure
  • Pre-existing hypertension
  • Not to be substituted for corticosteroids insufficiency
  • Abrupt discontinuation may lead to disease insufficiency
  • Anemia
  • Pre-existing asthma

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