Composition
Diclofenac Diethylamine – 2% w/v
Methyl Salicylate – 10% w/v
Peppermint Oil – 10% w/v
Turpentine Oil – 10% w/v
Eucalyptus Oil – 5% w/v
Benzyl Alcohol – 1% v/v
Packing
50 ml
Product Description
Movogesic oil contains Diclofenac diethyl, methyl salicylate, peppermint oil, turpentine oil, eucalyptus oil and benzyl alcohol.
Diclofenac diethyl
It is NSAID and applied to skin to reduce the inflammation and to reduce pain.
Methyl salicylate
It is organic ester extracted from plant species mainly wintergreens. It is also used synthetically as fragrance in foods and beverages. When they applied to the skin it causes sudden cooling and warm feeling.
Oils in the preparation
Peppermint oil has anti-inflammatory properties causing calming and numbing effect. It may provide relief from stress, depression and mental exhaustion.
Indication
- Musculoskeletal complaints
- Arthritis
- Rheumatoid arthritis
- Polymyositis
- Dermatomyositis
- Osteoarthritis
- Spondylarthritis or Ankylosing spondylitis
- Gout attacks
- Acute migraines
- Post operative and post traumatic pain
- Inflammation
- Actinic keratosis
- Pains associated with minor strains, sprains and contusions
Mechanism of action
Diclofenac diethyl
It causes the inhibition of prostaglandin synthesis by causing the inhibition of COX. It also possesses bacteriostatic activity by inhibition of bacterial DNA synthesis.
Methyl salicylate
It is NSAIDs with analgesic properties. The action is caused by inhibition of PG synthesis. The primary metabolite of methyl salicylate is salicylate which inhibits the synthesis of PG by irreversibly acetylating and inactivating COX.
Pharmacology
Diclofenac diethyl
Absorption
After dermal application it is well absorbed by the body about 100%. The drug follows first pass metabolism so 50% of the drug is systematically available. The mean absolute bioavailability is 55% and Tmax is 2.3 hr.
Distribution
The Vd is about 1.4l/kg. About 99% of the drug is bound to protein. The diclofenac converts to its metabolites like 4′-hydroxy-, 5-hydroxy-, 3′-hydroxy-, 4′,5-dihydroxy- and 3’hydroxy-4′-methoxy-diclofenac.
Excretion
The drug is excreted through urinary and biliary secretion.
Methysalicylate
Absorption
The dermal bioavailability is 11.8%-30.7%. The presence of methyl- salicylate causes more penetration into the skin.
Distribution
It is distributed throughout the body tissues. Salicylate is transported by low capacity saturated system out of the CSF. It follows hepatic metabolism which form conjugation with glycine to form salicyluric acid.
Excretion
It is excreted in free form in urine as salicylate acid (10%) salicyluric acid (75%), salicylic phenolic (10%) and acyl (5%) glucuronides, and gentisic acid (less than 1%). Excretion depends on the pH of the urine.
Contraindications
- Hypersensitivity against diclofenac
- Associated allergic reactions
- Third trimester of pregnancy
- Patients with GI bleeding
- Patients with pre-existing hepatic porphyria
- Fluid retention and heart failure
- Pre-existing hypertension
Precautions
- Not to be substituted for corticosteroids insufficiency
- Abrupt discontinuation may lead to disease insufficiency
- Anemia
- Pre-existing asthma