Nimesulide    –   100 mg

Mouth dissolving

Each box contain 20 Blister strips of 10 tablets

Nicare MD contains nimesulide which is in mouth dissolving form of tablet. Nimesulide is selective COX-2 NSAID which possesses analgesic and antipyretic properties. It is mainly used for the treatment of acute pain, osteoarthritis and primary dysmenorrhoea in adolescents.

• Painful inflammatory conditions
• Back pain
• Dysmenorrhea
• Postoperative pain
• Osteoarthritis
• Fever

Nimesulide

It produces its therapeutic effect by targeting the key mediators of inflammatory process which includes COX-2 mediated prostaglandins, free radicals, histamine and proteolytic enzymes.

Absorption

After oral administration it is rapidly adsorbed by the body.

Distribution

It undergoes extensive biotransformation to 4-hydroxynimesulide which is a biologically active form of the drug. The drug produces its pharmacological effect within 15mins from the drug intake. The protein binding of the drug is more than 97.5%

Excretion

The half life of the drug is 1.8–4.7 hours. About 50% of the drug is excreted through kidney and 29% in feces.

• Severe hepatic disease
• Severe kidney disease
• Bleeding disorder
• Hypersensitivity
• Stomach problems
• Gastrointestinal ulcers

• Diabetes mellitus
• Alcohol abuse
• Colitis
• Crohn’s disease
• Diverticulitis
• Gastric ulcer