Nicare MD tablet 2018-09-09T16:49:22+00:00

Nimesulide    –   100 mg

Mouth dissolving

Each box contain 20 Blister strips of 10 tablets

Nicare MD contains nimesulide which is in mouth dissolving form of tablet. Nimesulide is selective COX-2 NSAID which possesses analgesic and antipyretic properties. It is mainly used for the treatment of acute pain, osteoarthritis and primary dysmenorrhoea in adolescents.

  • Painful inflammatory conditions
  • Back pain
  • Dysmenorrhea
  • Postoperative pain
  • Osteoarthritis
  • Fever

Nimesulide

It produces its therapeutic effect by targeting the key mediators of inflammatory process which includes COX-2 mediated prostaglandins, free radicals, histamine and proteolytic enzymes.

 

Absorption

After oral administration it is rapidly adsorbed by the body.

Distribution

It undergoes extensive biotransformation to 4-hydroxynimesulide which is a biologically active form of the drug. The drug produces its pharmacological effect within 15mins from the drug intake. The protein binding of the drug is more than 97.5%

Excretion

The half life of the drug is 1.8–4.7 hours. About 50% of the drug is excreted through kidney and 29% in feces.

  • Severe hepatic disease
  • Severe kidney disease
  • Bleeding disorder
  • Hypersensitivity
  • Stomach problems
  • Gastrointestinal ulcers
  • Diabetes mellitus
  • Alcohol abuse
  • Colitis
  • Crohn’s disease
  • Diverticulitis
  • Gastric ulcer 

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