Composition
Nimesulide – 100 mg
Paracetamol – 325 mg
Packing
Each box contain 10 Blister strips of 10 tablets
Product Description
Nimesulide
It is selective COX-2 NSAID which possesses analgesic and antipyretic properties. It is mainly used for the treatment of acute pain, osteoarthritis and primary dysmenorrhoea in adolescents.
Paracetamol
It is also known as acetaminophen and is widely used as over the counter analgesic and anti-pyretic. It is a mild analgesic which causes relief in mild headaches and other aches and pains. In combination with other drugs like opioid analgesic, paracetamol is used in the management of post surgical pain and severe pain.
Indication
- Acute pain
- Treatment of osteoarthritis
- Dysmenorrhoea in adolescents
- Analgesic and antipyretic
Mechanism of action
Nimesulide
It produces its therapeutic effect by targeting the key mediators of inflammatory process which includes COX-2 mediated prostaglandins, free radicals, histamine and proteolytic enzymes.
Paracetamol
It inhibits the synthesis of prostaglandin synthesis by competing with arachidonic acid for the active site of COX.
Pharmacology
Paracetamol
Absorption
It has rapid and complete absorption
Distribution
The protein binding of the drug is about 25%, it undergoes glucuronidation in liver.
Excretion
About 80% of acetaminophen is excreted in the urine after conjugation and about 3% of the drug is excreted unchanged.
Nimesulide
Absorption
After oral administration it is rapidly adsorbed by the body.
Distribution
It undergoes extensive biotransformation to 4-hydroxynimesulide which is a biologically active form of the drug. The drug produces its pharmacological effect within 15mins from the drug intake. The protein binding of the drug is more than 97.5%
Excretion
The half life of the drug is 1.8–4.7 hours. About 50% of the drug is excreted through kidney and 29% in feces.
Contraindications
- Hepatic and renal impairment
- Children under the 12yrs of age
- In pregnant and lactating mothers
- Patients with gastric bleeding, ulcer
- Severe hepatic disease
- Severe kidney disease
- Bleeding disorder
- Hypersensitivity
- Stomach problems
- Gastrointestinal ulcers
Precautions
- Patients with the history of stomach problem
- High blood pressure
- Fluid retention
- Pregnancy and breast feeding mothers.
- Diabetes mellitus
- Alcohol abuse
- Colitis
- Crohn’s disease
- Diverticulitis
- Gastric ulcer