Composition
Paracetamol – 650 mg
Packing
Each box contain 10 Blister strips of 10 tablets
Product Description
Rexol 650 contains paracetamol. It is also known as acetaminophen and is widely used as over the counter analgesic and anti-pyretic. It is a mild analgesic which causes relief in mild headaches and other aches and pains. In combination with other drugs like opioid analgesic, paracetamol is used in the management of post surgical pain and severe pain.
Indication
- Acute pain
- Analgesic
- Anti-pyretic
- Migraine headaches
- Dysmenorrhea
- Joint pain
Mechanism of action
It inhibits the synthesis of prostaglandin synthesis by competing with arachidonic acid for the active site of COX.
Pharmacology
Absorption
It has rapid and complete absorption
Distribution
The protein binding of the drug is about 25%, it undergoes glucuronidation in liver.
Excretion
About 80% of acetaminophen is excreted in the urine after conjugation and about 3% of the drug is excreted unchanged.
Contraindications
- Liver Failure
- Liver Problems
- Serious Kidney Problems
- Shock
- Overdose of the Drug Acetaminophen
- Poor Nutrition
Precautions
- Any allergies
- Liver disease
- Alcohol abuse
- Chewable tablet may contain sugar or aspartame should not be used in diabetic patients