Sytrax tablets 2018-09-08T06:30:28+00:00

Etamsylate  –  250 mg

Tranexamic Acid  –  250 mg

Each box contain 3 Alu-Alu strips of 10 tablets

Sytrax is a combination of etamsylate and tranexamic acid.

Etamsylate is a haemostatic drug and is work by increasing capillary endometrial resistance and promoting platelet adhesion.

 Tranexamic acid is a synthetic analog of lysine amino acid. It is used to prevent excessive loss of blood during surgery and in various types of disorder and surgery. It is an anti-fibrinolytic which inhibits the activation of plasminogen to plasmin.

  • Prevention of excessive bleeding
  • Reduces the requirement of blood clotting factor tansfusion during operation
  • It is antifibrinolytic agent
  • Blocks the breakdown of blood clot

Tranexamic Acid

It completely inhibits the activation of plasminogen which causes reduction in the conversion of plasminogen to plasmin. It also inhibits plasmin activity.

Etamsylate

It is a haemostatic agent, which promotes angioprotective and proaggregant action. It also stimulates thrombopoiesis and its release from the bone marrow. The drug produces haemostaticaction due to activation of thromoblastin formation on the small damaged blood vessels and decreased PgI2 synthesis. It reduces the bleeding time and blood loss from the wound healing.

Tranexamic Acid

Absorption

After oral administration the drug is 30-50% absorbed. The bioavailability of the drug is not affected by the food intake.

Distribution

The total volume of distribution is about 9 to 12 L. The plasma protein binding is about 3%. Less than 5% of the drug is metabolized.

Excretion

The drug follows urinary excretion through glomerular filtration

Etamsylate

Absorption

After oral administration it is well absorbed

Distribution

The drug is bound to protein and well distributed

Excretion

The drug is excreted through urine in unchanged form

  • Hypersensitivity to any ingredient of the drug
  • Porphyria
  • Haemophilia
  • Thrombocytopenic purpura
  • Thromboembolic disorders
  • Massive upper urinary tract haemorrhage
  • Color vision disorders
  • Subarachnoid haemorrhage
  • Severe renal impairment
  • Hepatic impairment
  • Monitor liver functioning during long term use
  • Dose adjustment is required with renal impairment
  • Avoid IV administration

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