ULCRATE O 2018-09-09T12:18:18+00:00

Sucralfate   –   1000 mg

Oxetacaine   –   20 mg

Each carton contain 100 ml bottle

ULCRATE O suspension contains sucralfate and oxetacaine.

Sucralfate is a cytoprotective agent in oral dosage form. It is used for the treatment of duodenal ulcers. It is sucrose sulfate-aluminium complex which binds to the mucosa, thus creating a physical barrier which protects the mucosa from acid.

Oxetacaine is a local anesthetic. It is used orally for management of the hemorrhoid pain and relief associated with peptic ulcer disease.

  • Short term treatment for duodenal ulcer
  • Maintenance therapy for duodenal ulcer patient
  • GERD
  • Peptic ulcer
  • Hemorrhoid pain
  • Gastric / Duodenal ulcer

Sucralfate

It protects the gastro-intestinal lining of the stomach from peptic acid, pepsin and bile salts by binding with the exudates and forming a viscous layer. This viscous layer is protective the GI tract lining from acid.

Oxcetacaine produces the reversible loss of sensation by blocking the conduction of nerve impulse. This causes decrease in permeability of sodium ions across the membrane in stomach. It increases the stomach pH and causes relief in hyperacidity.

The presence of aluminium hydroxide and magnesium hydroxide reacts chemically to neutralize the acid by forming the coating over the inflamed mucosa.

Sucralfate

Absorption

The absorption of the drug is less than 5% after oral administration
Distribution

After oral administration the drug acts on site of ulcer. The onset of action is 2hrs. The duration of action of the drug is 6hrs.

Excretion

The drug is mainly excreted in urine

Oxcetacaine

Absorption

The drug after administration reduces the acid in the stomach. The adhering property of aluminum and magnesium as vehicle with drug preparation causes oxetacaine to cause topical anesthetic action. Very small amount of aluminum and magnesium is absorbed by the bowel.

Distribution

It produces local action in presence of acid

Excretion

The absorbed form is excreted in urine

  • Hypersensitivity to any of the ingredient
  • Low level of phosphate in blood
  • Renal impairment
  • Use of drug in special population i.e pregnant or pediatric patients
  • Treatment is not considered for post healing of duodenal ulceration.
  • Aluminium hydroxide is absorbed in the GI tract so can increase the concentration of the drug in body after administration of other dose of antacid.

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