Rabeprazole - 20 mg
Levosulpiride - 75 mg
(Sustained release pellets)
10x10 Alu-Alu
Aciraz-LS is a combination of rabeprazole and levosulpiride.
Rabeprazole
It is a proton pump inhibitor which inhibits the secretion of gastric acid. It belongs to the same class as that of omeprazole.
Levosulpiride
It is a benzamide class of antipsychotic drug. It is mainly used for the treatment of psychosis and major depressive disorder. Levosulpiride is levo-isomer.
Rabeprazole
It is PPI which suppresses the gastric acid production. It acts by suppressing the final step in gastric acid formation. It produces dose related response.
Levosulpiride
It acts as D2 receptor antagonist. It is a moderate antagonist at 5HT receptor. This property enhances its therapeutics efficacy in gastrointestinal disorder. This property with D2 receptor antagonism contributes its GI pk effect.
Rabeprazole
Absorption
After oral administration it is well absorbed in the body.
Distribution
The drug is metabolized by the liver with Cmax about 2.5mcg/ml. the peak concentration of the drug is about 2.5hrs. The apparent volume of distribution is 11.0-23.6 L.
Excretion
About 18% of the drug is excreted in feces through biliary excretion.
Levosulpiride
Absorption
It is well absorbed in the body with oral bioavailability about 30% with peak plasma concentration achieving in 3hrs.
Excretion
The drug is excreted through urine with plasma half life 4.3hr.
