Levofloxacin 500 mg
10 x 10
Blister
Levofloxacin is a fluoroquinoline class of drug. It is a broad spectrum antibiotic, having levo-isomer for its predecessor ofloxacin. It produces its activity against most of the bacterial infections. It produces more activity towards gram positive bacteria and lesser towards negative bacteria. For categorizing levofloxacin from other fluoroquinolines it is called as “respiratory quinolines”.
These classes of drugs are valued for its broad spectrum of activity and better tissue penetration. It is mainly used in combination of antibacterial drugs to particular infections.
Levofloxacin is a broad spectrum antibiotic. It is active against both gram positive and gram negative bacteria. It produces the effect by two type of topoisomerase enzymes II i.e DNA gyrase and topoisomerase. Topoisomerase IV is necessary for separation of DNA that has been replicated prior to the bacterial cell divisions. The DNA not being replicated stops the process of bacterial division. Levofloxacin mainly produces bactericidal action; both the mechanisms involved in killing of the bacteria and also produce effect on DNA metabolism.
Absorption
After oral administration it is rapidly absorbed. The maximum plasma concentration achieved in 1-2 hrs. The bioavailability is 99%. The peak plasma concentration achieved in 1hr is 6.2±1.0 mcg/mL
Distribution
Levofloxacin attains a large volume of distribution about 74 to 112L after single or multiple doses. It is widely distributed in the tissue fluids in about 3hrs. It gets widely distributed into the tissues of lungs.
Excretion
The drug is excreted in unchanged form in urine. The plasma elimination of the drug ranges from 6-8hrs with multiple doses. The total renal clearance ranges from 96- 142 mL/min. The renal clearance is from glomerular filtration.
