Dispo Pack

Nervoba 2500 Injection contains methylcobalamin. It is a form of vitaminB12. It is a cobalamin which differs from cyanocobalamin. The cyanide group is replaced by methyl group in methylcobalamin. Octahedral cobalt III is present in the centre.

• Megaloblastic anemia caused by vitB12 deficiency
• Peripheral neuropathy
• Diabetic neuropathy
• Pernicious anemia
• Amyotrophic lateral sclerosis

It is the active form of vitamin B12 which a water soluble vitamin. It functions as to transfer methyl group for the regeneration of methionine from homocysteine. It acts as a cofactor for enzyme methionin synthase. In cases of anemia it causes the production of erythrocytes by nucleic acid synthesis in bone marrow.

Absorption

The drug is well absorbed in the body with peak concentration achieved after 3hrs.

Distribution

After oral administration it is well distributed

Excretion

The drug is excreted through urine.

• Decreases the GI absorption with neomycin
• Reduces the serum concentrations of oral contraceptives

• Polycythemia rubra vera
• Megaloblastic anemia
• Cobalt or cobalamin allergy
• Leber’s disease.