Omeprazole - 20 mg
Domperidone - 10 mg
10x10 Alu-Alu
Razom D capsules contain Omeprazole and Domperidone.
Omeprazole
It is a proton pump inhibitor. It is available as over the counter drug. It is mainly used for the treatment of dyspepsia, peptic ulcer or GERD.
Domperidone
It is a specific blocker of dopamine receptor. It is used to relieve nausea, vomiting, to increase the transit of food through the stomach.
Omeprazole
It is a proton pump inhibitor that suppresses the secretion of gastric acid by inhibiting H+/K+ – ATPase enzymes. It has short plasma half life. It blocks the final step in acid production and thus causes reduction in gastric acidity.
Domperidone
It increases the peristaltic stimulation. It facilitates the gastric emptying and decreases the small bowel transit time by increasing the esophageal and gastric peristalsis. The antiemetic property is related to blocking of dopamine activity.
Omeprazole
Absorption
It follows rapid absorption with plasma concentration of 0.5 to 3.5 hrs.
Distribution
The protein binding of the drug is 95% and the drug is metabolized by the enzyme cytochrome P450 (CYP)
Excretion
The drug is excreted in unchanged form in urine.
Domperidone
Absorption
The drug follows rapid absorption
Distribution
About 91%-93% of the drug is bound to plasma protein.
Excretion
About 31-66% of the drug is excreted through urinary and fecal secretion.
