20X10 Blister

Verdrot 40 contains drotaverine. It is an anti-spasmodic drug which is structurally related to papaverine. It has no anticholinergic effect and is a selective phosphodiesterase 4 inhibitor. Drotaverine is shown to possess a dose dependent analgesic effect.  

• Antispasmodic
• Cholangitis
• Cholecystitis
• Cholecytolithiasis
• Cystitis
• Nephrolithiasis
• Smooth muscle spasm
• Stone formation
• Ureterolithiasis
• Vesical tenesmus
• Papilitis

It is an anti-spasmodic drug which produces its effect by inhibition of phosphodiasterase-4 which is specific for smooth muscle. It produces its fast duration of action on smooth muscle. It maintains the cAMP and Ca balance at spastic site, thereby relieving smooth muscle spasm and pain.

Absorption

After administration it is well absorbed in the body. It is a spasmolytic agent by inhibiting phosphodiesterase enzyme 4 in smooth muscle cells. Bioavailability of the drug is highly variable. It get rapidly absorbed from duodenal ileal segments

Distribution:

The protein binding of the drug is about 80-95%. The drug follows hepatic metabolism. The half life of the drug is 7 to 12hrs.

Excretion:

The excretion of the drug is through biliary excretion and feces.

• Patients hypersensitive to its ingredients
• Its use in pregnancy, especially in first and third trimester
• In severe cases of hepatic, renal, cardiac dysfunction.

• Cautiously used in patients with hepatic, renal and cadiac dysfunction
• Patients with pregnancy and lactation