Each box contain 10 Alu-Alu strips of 10 tablets

Zynhist-25 is an antihistamine medication containing Hydroxyzine, an effective and well-established compound with a composition of 25 mg per tablet. Belonging to the class of piperazine derivatives, Hydroxyzine is widely recognized for its anti-allergic and anxiolytic properties.

• Relief of allergy symptoms
• Management of anxiety and tension
• Treatment of pruritus (itching) caused by allergic conditions
• As a sedative for preoperative and postoperative care
• Adjunctive therapy in organic disease states

Hydroxyzine, a first-generation antihistamine, exerts its effects by selectively antagonizing histamine H1 receptors. By blocking the action of histamine, it alleviates symptoms such as itching, sneezing, and runny nose associated with allergic reactions. Additionally, Hydroxyzine has an anxiolytic effect, contributing to its use in managing anxiety.

Absorption:

Zynhist-25 is well-absorbed following oral administration, with its effects not significantly influenced by food intake.

Distribution:

The medication exhibits a wide distribution throughout the body. Its binding to plasma proteins varies, with a concentration-dependent relationship. Hydroxyzine can cross the blood-brain barrier, contributing to its central nervous system effects.

Excretion:

Hydroxyzine undergoes hepatic metabolism to form its active metabolite, cetirizine, which further contributes to its therapeutic effects. The drug and its metabolites are primarily excreted in the urine.

Zynhist-25 is contraindicated in individuals with:

• Known hypersensitivity to Hydroxyzine or any of its components
• Acute porphyria
• During early pregnancy

• Avoid use in elderly patients with cognitive impairment
• Use with caution in patients with hepatic impairment
• May cause drowsiness; caution with activities requiring mental alertness
• Avoid alcohol consumption during treatment

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